There are not a lot of choices when it comes to ITX cases that offer room for system expansion.  Many ITX cases focus on super small size and therefore cannot utilize full-sized Optical Drives, card readers or multiple hard drives.  The Element Q from Thermaltake allows you to install your favorite Blu-Ray burner, a pair of 3.5" hard drives and more. . .

Thermaltake Element Q ITX Case Review - BCCHardware